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| St. Petersburg Open | ||
| Surface: Hard | Date: Sep. 17 - Sep. 23 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Adrian Menendez-Maceiras | Win | 7-6 (7-3), 6-2 |
| Second Round | Matteo Berrettini | Win | 7-6 (8-6), 4-6, 6-0 |
| Quarterfinals | Martin Klizan |
| US Open | ||
| Surface: Hard | Date: Aug. 27 - Sep. 9 | Seed: 28 |
| Round | Opponent | W / L | Result |
| First Round | Felix Auger-Aliassime | Win | 7-5, 5-7, 4-1 Retired |
| Second Round | Andreas Seppi | Win | 6-4, 4-6, 5-7, 7-6(7-2), 6-4 |
| Third Round | Kevin Anderson | Loss | 6-4, 3-6, 4-6, 6-4, 4-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 12 - Aug. 19 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Frances Tiafoe | Win | 7-6 (8-6), 3-6, 7-5 |
| Second Round | Kyle Edmund | Win | 6-4, 7-5 |
| Third Round | Milos Raonic | Loss | 6-7 (6-8), 4-6 |
| Rogers Cup presented by National Bank | ||
| Surface: Hard | Date: Aug. 6 - Aug. 12 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Jeremy Chardy | Win | 6-1, 6-4 |
| Second Round | Fabio Fognini | Win | 6-3, 7-5 |
| Third Round | Robin Haase | Loss | 5-7, 2-6 |
| Citi Open | ||
| Surface: Hard | Date: Jul. 30 - Aug. 5 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Daniil Medvedev | Win | 3-6, 6-1, 6-4 |
| Third Round | Kei Nishikori | Loss | 6-7 (1-7), 3-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 2 - Jul. 15 | Seed: 26 |
| Round | Opponent | W / L | Result |
| First Round | Jeremy Chardy | Win | 6-3, 3-6, 7-5, 6-4 |
| Second Round | Benoit Paire | Loss | 6-0, 2-6, 4-6, 6-7 (3-7) |
| Nature Valley International | ||
| Surface: Grass | Date: Jun. 24 - Jun. 30 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jared Donaldson | Win | 6-4, 4-6, 6-2 |
| Quarterfinals | Mischa Zverev | Loss | 3-6, 3-6 |
| Fever-Tree Championships | ||
| Surface: Grass | Date: Jun. 18 - Jun. 24 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Gilles Muller | Loss | 6-7 (7-9), 6-7 (6-8) |
| MercedesCup | ||
| Surface: Grass | Date: Jun. 11 - Jun. 17 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Prajnesh Gunneswaran | Loss | 6-7 (6-8), 6-2, 3-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 27 - Jun. 10 | Seed: 24 |
| Round | Opponent | W / L | Result |
| First Round | John Millman | Win | 7-5, 6-4, 6-2 |
| Second Round | Maximilian Marterer | Loss | 7-5, 6-7 (4-7), 5-7, 4-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 13 - May 20 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Tomas Berdych | Win | 1-6, 6-3, 7-6 (7-5) |
| Second Round | Robin Haase | Win | 7-6 (7-3), 6-7 (5-7), 6-3 |
| Third Round | Rafael Nadal | Loss | 4-6, 1-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 5 - May 13 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Tennys Sandgren | Win | 6-1, 6-4 |
| Second Round | Benoit Paire | Win | 7-6 (7-5), 4-6, 6-4 |
| Third Round | Milos Raonic | Win | 6-4, 6-4 |
| Quarterfinals | Kyle Edmund | Win | 7-5, 6-7 (6-8), 6-4 |
| Semifinals | Alexander Zverev | Loss | 4-6, 1-6 |
| Gazprom Hungarian Open | ||
| Surface: Red Clay | Date: Apr. 23 - Apr. 29 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Nikoloz Basilashvili | Loss | 2-6, 4-6 |
| Monte-Carlo Rolex Masters | ||
| Surface: Clay | Date: Apr. 15 - Apr. 22 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Stefanos Tsitsipas | Loss | 3-6, 4-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 20 - Apr. 1 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Viktor Troicki | Win | 6-3, 6-7 (4-7), 7-6 (8-6) |
| Second Round | Damir Dzumhur | Win | 6-1, 7-5 |
| Third Round | Sam Querrey | Win | 6-4, 3-6, 7-5 |
| Fourth Round | Borna Coric | Loss | 6-7 (2-7), 6-4, 4-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 7 - Mar. 18 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Ricardas Berankis | Win | 6-3, 6-4 |
| Second Round | Pablo Cuevas | Loss | 6-7 (4-7), 3-6 |
| Abierto Mexicano TELCEL | ||
| Surface: Hard | Date: Feb. 26 - Mar. 3 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Kei Nishikori | Win | 6-7 (3-7), 6-3, 6-1 |
| Second Round | Dominic Thiem | Loss | 2-6, 3-6 |
| Delray Beach Open | ||
| Surface: Hard | Date: Feb. 19 - Feb. 25 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Ivo Karlovic | Win | 7-5, 7-6 (7-4) |
| Second Round | Jared Donaldson | Win | 6-7 (6-8), 6-4, 6-4 |
| Quarterfinals | Taylor Fritz | Win | 7-5, 6-4 |
| Semifinals | Frances Tiafoe | Loss | 5-7, 4-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 28 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Stefanos Tsitsipas | Win | 6-1, 6-3, 7-6 (7-5) |
| Second Round | Jo-Wilfried Tsonga | Loss | 6-3, 3-6, 6-1, 6-7 (4-7), 5-7 |
| ASB Classic | ||
| Surface: Hard | Date: Jan. 1 - Jan. 13 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Rogerio Dutra Silva | Win | 6-3, 6-2 |
| Second Round | Juan Martin Del Potro | Loss | 2-6, 4-6 |
| Brisbane International presented by Suncorp | ||
| Surface: Hard | Date: Dec. 31 - Jan. 7 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Kyle Edmund | Loss | 7-6 (7-5), 6-7 (4-7), 4-6 |
© 2018 by STATS.